منابع مشابه
Stress granules
Cell growth and proliferation are fundamental processes in living organisms and are dynamically controlled by environmental cues. TOR complex 1 (TORC1) is a central protein kinase involved in the regulation of cell growth in response to a wide variety of cellular states and is the target of the immunosuppressant and anticancer drug rapamycin. In the budding yeast Saccharomyces cerevisiae, TORC1...
متن کاملStress granules
What are stress granules? Stress granules are non-membranous cytoplasmic foci ranging in size from 0.1 to 2.0 μm, composed of non-translating messenger ribonucleoproteins (mRNPs) that rapidly aggregate in cells exposed to adverse environmental conditions. Their assembly is triggered by a variety of environmental stresses including heat shock, oxidative stress, hyperosmolarity, viral infection, ...
متن کاملNuclear stress granules
Nuclear stress granules are subnuclear compartments that form in response to heat shock and other stress stimuli. Although many components of nuclear stress granules have been identified, including HSF1 and pre-mRNA processing factors, their function remains a mystery. A paper in this issue describes the stress-induced transcriptional activation of one of the nuclear stress granule target sites...
متن کاملStress granules and Plasmodium liver stage infection
Organisms have evolved numerous strategies to control infection by an array of intracellular pathogens. One cell autonomous pathogen control strategy is global inhibition of protein synthesis via stress granule (SG) formation. SGs are induced by stressful stimuli such as oxidative stress and nutrient deprivation, and are known to counteract both viral and bacterial infections. Pathogens, in tur...
متن کاملStress granules ease the way for metastasis
The mitotic checkpoint protein hSpindly must be farnesy-lated at its C terminus in order to be recruited to kinetochores, < a d d a r t t y p e = " r e l " d o i = " 1 0. 1 0 8 3 / j c b. 2 0 1 4 1 2 0 8 5 " > Moudgil et al.< / a d d a r t > reveal. Mitotic checkpoint proteins assemble on kineto-chores and prevent chromosomes from segregating until they are properly attached to the mitotic spin...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2012
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.22044